我们的邮件系统环境是：AD+Exchange windows2003
用nslookup 查询域名的mx记录没有问题。
我们的域名也做了反向解析
在Exchange2007 邮件查看器队列显示：
451 4.4.0 Primary Target Ip address responded with:"421 4.4.1 Unable to connect." Attempted failover to alternate host, but that did not succeed.Either there are no alternate hosts,or delivery failed to all alternate hosts.
下面是部分日志文件：
#Software: Microsoft Exchange Server
#Version: 8.0.0.0
#Log-type: SMTP Send Protocol Log
#Date: 2012-10-25T00:04:30.866Z
#Fields: date-time,connector-id,session-id,sequence-number,local-endpoint,remote-endpoint,event,data,context
2012-10-25T00:04:44.085Z,Send,08CF75A503874A31,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:04:57.507Z,Send,08CF75A503874A31,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10060, Error Message: 由于连接方在一段时间后没有正确答复或连接的主机没有反应，连接尝试失败。 208.65.144.12:25"
2012-10-25T00:04:57.507Z,Send,08CF75A503874A31,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:04:58.898Z,Send,08CF75A503874A31,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:04:58.898Z,Send,08CF75A503874A31,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:05:00.320Z,Send,08CF75A503874A31,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:05:00.320Z,Send,08CF75A503874A31,0,,208.65.144.13:25,*,,attempting to connect
2012-10-25T00:05:13.695Z,Send,08CF75A503874A31,1,,208.65.144.13:25,*,,"Failed to connect. Error Code: 10060, Error Message: 由于连接方在一段时间后没有正确答复或连接的主机没有反应，连接尝试失败。 208.65.144.13:25"
2012-10-25T00:05:13.695Z,Send,08CF75A503874A31,0,,208.65.145.13:25,*,,attempting to connect
2012-10-25T00:05:15.086Z,Send,08CF75A503874A31,1,,208.65.145.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.13:25"
2012-10-25T00:05:15.101Z,Send,08CF75A503874A31,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:05:16.789Z,Send,08CF75A503874A31,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.12:25"
2012-10-25T00:05:21.086Z,Send,08CF75A503874A32,0,,119.147.192.101:25,*,,attempting to connect
2012-10-25T00:08:32.043Z,Send,08CF75A503874A37,0,,208.65.144.2:25,*,,attempting to connect
2012-10-25T00:08:33.730Z,Send,08CF75A503874A37,1,,208.65.144.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.2:25"
2012-10-25T00:08:33.730Z,Send,08CF75A503874A37,0,,208.65.145.2:25,*,,attempting to connect
2012-10-25T00:08:35.152Z,Send,08CF75A503874A37,1,,208.65.145.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.2:25"
2012-10-25T00:08:35.152Z,Send,08CF75A503874A37,0,,208.65.144.2:25,*,,attempting to connect
2012-10-25T00:08:36.855Z,Send,08CF75A503874A37,1,,208.65.144.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.2:25"
2012-10-25T00:08:36.855Z,Send,08CF75A503874A37,0,,208.65.144.3:25,*,,attempting to connect
2012-10-25T00:08:38.183Z,Send,08CF75A503874A37,1,,208.65.144.3:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.3:25"
2012-10-25T00:08:38.183Z,Send,08CF75A503874A37,0,,208.65.145.3:25,*,,attempting to connect
2012-10-25T00:08:39.590Z,Send,08CF75A503874A37,1,,208.65.145.3:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.3:25"
2012-10-25T00:08:39.590Z,Send,08CF75A503874A37,0,,208.65.145.2:25,*,,attempting to connect
2012-10-25T00:08:46.418Z,Send,08CF75A503874A37,1,,208.65.145.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.2:25"
2012-10-25T00:15:16.816Z,Send,08CF75A503874A3B,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:15:18.519Z,Send,08CF75A503874A3B,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.12:25"
2012-10-25T00:15:18.519Z,Send,08CF75A503874A3B,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:15:25.363Z,Send,08CF75A503874A3B,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:15:25.379Z,Send,08CF75A503874A3B,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:15:26.879Z,Send,08CF75A503874A3B,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:15:26.879Z,Send,08CF75A503874A3B,0,,208.65.144.13:25,*,,attempting to connect
2012-10-25T00:15:28.566Z,Send,08CF75A503874A3B,1,,208.65.144.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.13:25"
2012-10-25T00:15:28.566Z,Send,08CF75A503874A3B,0,,208.65.145.13:25,*,,attempting to connect
2012-10-25T00:15:29.894Z,Send,08CF75A503874A3B,1,,208.65.145.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.13:25"
2012-10-25T00:15:29.910Z,Send,08CF75A503874A3B,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:15:43.379Z,Send,08CF75A503874A3B,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10060, Error Message: 由于连接方在一段时间后没有正确答复或连接的主机没有反应，连接尝试失败。 208.65.144.12:25"
2012-10-25T00:18:46.429Z,Send,08CF75A503874A3C,0,,208.65.144.2:25,*,,attempting to connect
2012-10-25T00:18:48.117Z,Send,08CF75A503874A3C,1,,208.65.144.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.2:25"
2012-10-25T00:18:48.132Z,Send,08CF75A503874A3C,0,,208.65.144.3:25,*,,attempting to connect
2012-10-25T00:18:49.554Z,Send,08CF75A503874A3C,1,,208.65.144.3:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.3:25"
2012-10-25T00:18:49.570Z,Send,08CF75A503874A3C,0,,208.65.145.3:25,*,,attempting to connect
2012-10-25T00:18:50.961Z,Send,08CF75A503874A3C,1,,208.65.145.3:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.3:25"
2012-10-25T00:18:50.961Z,Send,08CF75A503874A3C,0,,208.65.145.2:25,*,,attempting to connect
2012-10-25T00:18:52.367Z,Send,08CF75A503874A3C,1,,208.65.145.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.2:25"
2012-10-25T00:18:52.367Z,Send,08CF75A503874A3C,0,,208.65.144.2:25,*,,attempting to connect
2012-10-25T00:19:05.773Z,Send,08CF75A503874A3C,1,,208.65.144.2:25,*,,"Failed to connect. Error Code: 10060, Error Message: 由于连接方在一段时间后没有正确答复或连接的主机没有反应，连接尝试失败。 208.65.144.2:25"
2012-10-25T00:19:05.789Z,Send,08CF75A503874A3C,0,,208.65.145.2:25,*,,attempting to connect
2012-10-25T00:19:07.258Z,Send,08CF75A503874A3C,1,,208.65.145.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.2:25"
2012-10-25T00:25:43.390Z,Send,08CF75A503874A46,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:25:56.766Z,Send,08CF75A503874A46,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10060, Error Message: 由于连接方在一段时间后没有正确答复或连接的主机没有反应，连接尝试失败。 208.65.144.12:25"
2012-10-25T00:25:56.766Z,Send,08CF75A503874A46,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:25:58.422Z,Send,08CF75A503874A46,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:25:58.422Z,Send,08CF75A503874A46,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:26:00.031Z,Send,08CF75A503874A46,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:26:00.031Z,Send,08CF75A503874A46,0,,208.65.144.13:25,*,,attempting to connect
2012-10-25T00:26:06.985Z,Send,08CF75A503874A46,1,,208.65.144.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.13:25"
2012-10-25T00:26:06.985Z,Send,08CF75A503874A46,0,,208.65.145.13:25,*,,attempting to connect
2012-10-25T00:26:08.422Z,Send,08CF75A503874A46,1,,208.65.145.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.13:25"
2012-10-25T00:26:08.422Z,Send,08CF75A503874A46,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:26:10.125Z,Send,08CF75A503874A46,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.12:25"
2012-10-25T00:29:07.269Z,Send,08CF75A503874A49,0,,208.65.144.2:25,*,,attempting to connect
2012-10-25T00:29:08.973Z,Send,08CF75A503874A49,1,,208.65.144.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.2:25"
2012-10-25T00:29:08.973Z,Send,08CF75A503874A49,0,,208.65.145.2:25,*,,attempting to connect
2012-10-25T00:29:10.660Z,Send,08CF75A503874A49,1,,208.65.145.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.2:25"
2012-10-25T00:29:10.660Z,Send,08CF75A503874A49,0,,208.65.144.2:25,*,,attempting to connect
2012-10-25T00:29:17.613Z,Send,08CF75A503874A49,1,,208.65.144.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.2:25"
2012-10-25T00:29:17.613Z,Send,08CF75A503874A49,0,,208.65.144.3:25,*,,attempting to connect
2012-10-25T00:29:19.035Z,Send,08CF75A503874A49,1,,208.65.144.3:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.3:25"
2012-10-25T00:29:19.035Z,Send,08CF75A503874A49,0,,208.65.145.3:25,*,,attempting to connect
2012-10-25T00:29:20.442Z,Send,08CF75A503874A49,1,,208.65.145.3:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.3:25"
2012-10-25T00:29:20.442Z,Send,08CF75A503874A49,0,,208.65.145.2:25,*,,attempting to connect
2012-10-25T00:29:22.129Z,Send,08CF75A503874A49,1,,208.65.145.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.2:25"
2012-10-25T00:36:10.137Z,Send,08CF75A503874A4C,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:36:11.840Z,Send,08CF75A503874A4C,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.12:25"
2012-10-25T00:36:11.840Z,Send,08CF75A503874A4C,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:36:13.559Z,Send,08CF75A503874A4C,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:36:13.559Z,Send,08CF75A503874A4C,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:36:20.590Z,Send,08CF75A503874A4C,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:36:20.590Z,Send,08CF75A503874A4C,0,,208.65.144.13:25,*,,attempting to connect
2012-10-25T00:36:22.293Z,Send,08CF75A503874A4C,1,,208.65.144.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.13:25"
2012-10-25T00:36:22.293Z,Send,08CF75A503874A4C,0,,208.65.145.13:25,*,,attempting to connect
2012-10-25T00:36:23.715Z,Send,08CF75A503874A4C,1,,208.65.145.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.13:25"
2012-10-25T00:36:23.715Z,Send,08CF75A503874A4C,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:36:30.747Z,Send,08CF75A503874A4C,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.12:25"
2012-10-25T00:39:22.141Z,Send,08CF75A503874A4D,0,,208.65.144.2:25,*,,attempting to connect
2012-10-25T00:39:29.188Z,Send,08CF75A503874A4D,1,,208.65.144.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.2:25"
2012-10-25T00:39:29.188Z,Send,08CF75A503874A4D,0,,208.65.145.2:25,*,,attempting to connect
2012-10-25T00:39:30.875Z,Send,08CF75A503874A4D,1,,208.65.145.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.2:25"
2012-10-25T00:39:30.875Z,Send,08CF75A503874A4D,0,,208.65.144.2:25,*,,attempting to connect
2012-10-25T00:39:32.610Z,Send,08CF75A503874A4D,1,,208.65.144.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.2:25"
2012-10-25T00:39:32.610Z,Send,08CF75A503874A4D,0,,208.65.144.3:25,*,,attempting to connect
2012-10-25T00:39:34.125Z,Send,08CF75A503874A4D,1,,208.65.144.3:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.3:25"
2012-10-25T00:39:34.125Z,Send,08CF75A503874A4D,0,,208.65.145.3:25,*,,attempting to connect
2012-10-25T00:39:35.531Z,Send,08CF75A503874A4D,1,,208.65.145.3:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.3:25"
2012-10-25T00:39:35.531Z,Send,08CF75A503874A4D,0,,208.65.145.2:25,*,,attempting to connect
2012-10-25T00:39:37.313Z,Send,08CF75A503874A4D,1,,208.65.145.2:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.2:25"
2012-10-25T00:46:31.039Z,Send,08CF75A503874A57,0,,208.65.145.12:25,*,,attempting to connect
2012-10-25T00:46:32.774Z,Send,08CF75A503874A57,1,,208.65.145.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.12:25"
2012-10-25T00:46:32.774Z,Send,08CF75A503874A57,0,,208.65.144.13:25,*,,attempting to connect
2012-10-25T00:46:34.477Z,Send,08CF75A503874A57,1,,208.65.144.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.13:25"
2012-10-25T00:46:34.477Z,Send,08CF75A503874A57,0,,208.65.145.13:25,*,,attempting to connect
2012-10-25T00:46:35.883Z,Send,08CF75A503874A57,1,,208.65.145.13:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.145.13:25"
2012-10-25T00:46:35.883Z,Send,08CF75A503874A57,0,,208.65.144.12:25,*,,attempting to connect
2012-10-25T00:46:37.586Z,Send,08CF75A503874A57,1,,208.65.144.12:25,*,,"Failed to connect. Error Code: 10061, Error Message: 由于目标机器积极拒绝，无法连接。 208.65.144.12:25"
2012-10-25T00:46:37.586Z,Send,08CF75A503874A57,0,,208.65.144.12:25,*,,attempting to connect